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00.250.50.7511.251.51.752+McCoy (DB RCT)80%0.20 [0.01-4.13]death0/1342/134Improvement, RR [CI]TreatmentControlCadegiani (DB RCT)92%0.08 [0.04-0.17]viral+7/17134/66Cadegiani (DB RCT)63%0.37 [0.02-8.85]death0/751/102Tau​2 = 0.00; I​2 = 0.0%Early treatment91%0.09 [0.04-0.19]7/38037/30291% improvementCadegiani (DB RCT)84%0.16 [0.11-0.24]death35/317197/328Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%Late treatment84%0.16 [0.11-0.24]35/317197/32884% improvementAll studies86%0.14 [0.10-0.20]42/697234/63086% improvement4 proxalutamide COVID-19 studiesc19proxalutamide.com 8/4/21Tau​2 = 0.01; I​2 = 3.6%; Z = 11.45 (p < 0.0001)Effect extraction pre-specifiedLower RiskIncreased Risk
7/25
Early Cadegiani et al., medRxiv, doi:10.1101/2021.07.24.21261047 (Preprint) Proxalutamide Improves Inflammatory, Immunologic, and Thrombogenic Markers in Mild-to-Moderate COVID-19 Males and Females: an Exploratory Analysis of a Randomized, Double-Blinded, Placebo-Controlled Trial Early Antiandrogen Therapy (EAT) with Proxalutamide (The EAT-Proxa Biochemical AndroCoV-Trial)
Details   Analysis of data from two proxalutamide early treatment RCTs with 445 patients showing substantial improvements in immunologic, inflammatory, thrombotic, and oxygen markers, which may support the observed reduction in hospitalization.
7/16
News Kintor Pharmaceutical News Release (News) news Kintor Pharmaceutical Receives Emergency Use Authorization for Proxalutamide for the Treatment of COVID-19 in Paraguay
Details   News release announcing that proxalutamide has been granted an emergency use authorization for COVID-19 in Paraguay.
7/10
Early Cadegiani et al., medRxiv, doi:10.1101/2021.07.06.21260086 (Preprint) death, ↓63.4%, p=1.00 Proxalutamide (GT0918) Reduces the Rate of Hospitalization in mild-to-moderate COVID-19 Female Patients: A Randomized Double-Blinded Placebo-Controlled Two-Arm Parallel Trial
Details   RCT 177 women in Brazil, 75 treated with proxalutamide, showing significantly lower hospitalization with treatment.
7/2
Late Zimerman et al., medRxiv, doi:10.1101/2021.06.28.21259661 (Preprint) Proxalutamide (GT0918) Reduction of Mortality Rate in Hospitalized COVID-19 Patients Depends on Treatment Duration - an Exploratory Analysis of the Proxa-Rescue AndroCoV Trial
Details   Analysis of treatment duration in the Proxa-Rescue AndroCoV trial showing significantly higher mortality among patients that interrupted treatment with proxalutamide. NCT04728802.
7/1
Late Medeiros et al., ResearchGate (Preprint) Proxalutamide (GT0918) Improves Lung Injury in Hospitalized COVID-19 Patients -an Analysis of the Radiological Findings of the Proxa-Rescue AndroCoV Trial
Details   Analysis of radiological findings from the Proxa-Rescue AndroCoV trial showing that proxalutamide significantly improves lung opacities compared to placebo. NCT04728802.
3/10
Late Cadegiani et al., medRxiv, doi:10.1101/2021.06.22.21259318 (results 3/10/21) (Preprint) death, ↓84.0%, p<0.0001 Efficacy of Proxalutamide in Hospitalized COVID-19 Patients: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Clinical Trial
Details   RCT 645 hospitalized patients, 317 treated with proxalutamide, showing significantly lower mortality and faster recovery with treatment. NCT04728802.
2/22
Early Cadegiani et al., Cureus, doi:10.7759/cureus.13492 (Peer Reviewed) viral+, ↓92.1%, p<0.0001 Proxalutamide Significantly Accelerates Viral Clearance and Reduces Time to Clinical Remission in Patients with Mild to Moderate COVID-19: Results from a Randomized, Double-Blinded, Placebo-Controlled Trial
Details   RCT 234 mild-moderate COVID-19 patients with 171 treated with proxalutamide, showing significantly faster viral clearance and recovery.
12/30
Early McCoy et al., Frontiers in Medicine, doi:10.3389/fmed.2021.668698 (preprint 12/30/2020) (Peer Reviewed) death, ↓80.0%, p=0.50 Proxalutamide (GT0918) Reduces the Rate of Hospitalization for COVID-19 Male Outpatients: A Randomized Double-Blinded Placebo-Controlled Trial
Details   RCT 268 male patients in Brazil, 134 treated with proxalutamide, showing significantly lower hospitalization and mechanical ventilation. NCT04446429.
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