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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Virological cure 92% Improvement Relative Risk Recovery 77% Recovery time 85% no CI Recovery time (b) 81% no CI c19proxalutamide.com/cadegiani2.html Favors proxalutamide Favors control
22 February 2021 - Early treatment study
Proxalutamide Significantly Accelerates Viral Clearance and Reduces Time to Clinical Remission in Patients with Mild to Moderate COVID-19: Results from a Randomized, Double-Blinded, Placebo-Controlled Trial
Cadegiani et al., Cureus, doi:10.7759/cureus.13492 (Peer Reviewed)
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RCT 234 mild-moderate COVID-19 patients with 171 treated with proxalutamide, showing significantly faster viral clearance and recovery. Third party analysis suggests potential randomization failure: [1].
risk of no virological cure, 92.1% lower, RR 0.08, p < 0.001, treatment 7 of 171 (4.1%), control 34 of 66 (51.5%), NNT 2.1, day 7, not including loss of taste or smell.
risk of no recovery, 76.8% lower, RR 0.23, p < 0.001, treatment 30 of 171 (17.5%), control 50 of 66 (75.8%), NNT 1.7, day 7, including loss of taste or smell.
recovery time, 85.0% lower, relative time 0.15, treatment 171, control 66, day 7, not including loss of taste or smell.
recovery time, 80.7% lower, relative time 0.19, treatment 171, control 66, day 7, including loss of taste or smell.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
This study is excluded in meta analysis: potential randomization failure based on a third-party analysis.
Cadegiani et al., 2/22/2021, Double Blind Randomized Controlled Trial, Brazil, South America, peer-reviewed, 8 authors, average treatment delay 4.2 days.
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