Cadegiani: Proxalutamide Significantly Accelerates Viral Clearance and Reduces Time to Clinical Remission in Patients with Mild to Moderate COVID-19: Results from a Randomized, Double-Blinded, Placebo-Controlled Trial

Cadegiani, 237 patient proxalutamide antiandrogen early treatment RCT: 92% improved viral clearance [p<0.0001] and 77% improved recovery [p<0.0001] https://c19p.org/cadegiani2

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Proxalutamide Significantly Accelerates Viral Clearance and Reduces Time to Clinical Remission in Patients with Mild to Moderate COVID-19: Results from a Randomized, Double-Blinded, Placebo-Controlled Trial

Cadegiani et al., Cureus, doi:10.7759/cureus.13492

22 Feb 2021 Source PDF Share Tweet

RCT 234 mild-moderate COVID-19 patients with 171 treated with proxalutamide, showing significantly faster viral clearance and recovery. Third party analysis suggests potential randomization failure: [steamtraen.blogspot.com].

1. steamtraen.blogspot.com, https://steamtraen.blogspot.com/20..plying-john-carlisles-table-1.html.

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risk of no viral clearance, 92.1% lower, RR 0.08, p < 0.001, treatment 7 of 171 (4.1%), control 34 of 66 (51.5%), NNT 2.1, day 7, not including loss of taste or smell.

risk of no recovery, 76.8% lower, RR 0.23, p < 0.001, treatment 30 of 171 (17.5%), control 50 of 66 (75.8%), NNT 1.7, day 7, including loss of taste or smell.

recovery time, 85.0% lower, relative time 0.15, treatment 171, control 66, day 7, not including loss of taste or smell.

recovery time, 80.7% lower, relative time 0.19, treatment 171, control 66, day 7, including loss of taste or smell.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

This study is excluded in meta analysis: potential randomization failure.

Cadegiani et al., 22 Feb 2021, Double Blind Randomized Controlled Trial, Brazil, peer-reviewed, 8 authors, average treatment delay 4.2 days.

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