RCT 590 hospitalized patients, 294 treated with proxalutamide showing significantly lower mortality and faster recovery.
Cadegiani et al., 3/10/2021, Double Blind Randomized Controlled Trial, Brazil, South America, preprint, baseline oxygen requirements 97.0%, 5 authors.
risk of death, 91.4% lower, RR 0.09, p < 0.001, treatment 12 of 294 (4.1%), control 141 of 296 (47.6%).
risk of mechanical ventilation, 91.6% lower, RR 0.08, p < 0.001, treatment 13 of 294 (4.4%), control 156 of 296 (52.7%).
recovery time, 84.2% lower, relative time 0.16, treatment 294, control 296.
hospitalization time, 64.3% lower, relative time 0.36, treatment 294, control 296.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
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