3/10 Late treatment study
et al., medRxiv, doi:10.1101/2021.06.22.21259318 (results 3/10/21) (Preprint)
Efficacy of Proxalutamide in Hospitalized COVID-19 Patients: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Clinical Trial
Efficacy of Proxalutamide in Hospitalized COVID-19 Patients: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Clinical Trial
RCT 645 hospitalized patients, 317 treated with proxalutamide, showing significantly lower mortality and faster recovery with treatment. NCT04728802.
risk of death, 84.0% lower, RR 0.16, p < 0.001, treatment 35 of 317 (11.0%), control 197 of 328 (60.1%), adjusted per study.
risk of mechanical ventilation, 88.8% lower, RR 0.11, p < 0.001, treatment 4 of 317 (1.3%), control 37 of 328 (11.3%).
risk of disease progression, 77.8% lower, RR 0.22, p < 0.001, treatment 36 of 317 (11.4%), control 168 of 328 (51.2%).
risk of no recovery, 72.5% lower, RR 0.28, p < 0.001, treatment 46 of 317 (14.5%), control 173 of 328 (52.7%).
recovery time, 50.0% lower, relative time 0.50, treatment 317, control 328.
hospitalization time, 33.3% lower, relative time 0.67, treatment 317, control 328.
Cadegiani et al., 3/10/2021, Double Blind Randomized Controlled Trial, Brazil, South America, preprint, 30 authors.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All
practical, effective, and safe means should be used. Elimination of COVID-19
is a race against viral evolution. No treatment, vaccine, or intervention is
100% available and effective for all current and future variants. Denying the
efficacy of any method increases the risk of COVID-19 becoming endemic; and
increases mortality, morbidity, and collateral damage. We do not provide
medical advice. Before taking any medication, consult a qualified physician
who can provide personalized advice and details of risks and benefits based
on your medical history and situation. Treatment protocols for physicians are
available from the FLCCC.