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Home   COVID-19 treatment studies for Proxalutamide  COVID-19 treatment studies for Proxalutamide  C19 studies: Proxalutamide  Proxalutamide   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Mortality 80% Improvement Relative Risk Ventilation 97% Hospitalization 91% c19proxalutamide.com McCoy et al. NCT04446429 Proxalutamide RCT EARLY TREATMENT Favors proxalutamide Favors control
McCoy, 268 patient proxalutamide early treatment RCT: 97% lower ventilation [p<0.0001] and 91% lower hospitalization [p<0.0001] https://c19p.org/mccoy
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Proxalutamide (GT0918) Reduces the Rate of Hospitalization for COVID-19 Male Outpatients: A Randomized Double-Blinded Placebo-Controlled Trial
McCoy et al., Frontiers in Medicine, doi:10.3389/fmed.2021.668698 (preprint 12/30/2020)
30 Dec 2020    Source   PDF   Share   Tweet
RCT 268 male patients in Brazil, 134 treated with proxalutamide, showing significantly lower hospitalization and mechanical ventilation. NCT04446429. Expression of concern: [frontiersin.org].
risk of death, 80.0% lower, RR 0.20, p = 0.50, treatment 0 of 134 (0.0%), control 2 of 134 (1.5%), NNT 67, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of mechanical ventilation, 97.1% lower, RR 0.03, p < 0.001, treatment 0 of 134 (0.0%), control 17 of 134 (12.7%), NNT 7.9, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 91.0% lower, RR 0.09, p < 0.001, treatment 3 of 134 (2.2%), control 35 of 134 (26.1%), NNT 4.2.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
McCoy et al., 12/30/2020, Double Blind Randomized Controlled Trial, Brazil, South America, peer-reviewed, 15 authors, trial NCT04446429.
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